Lifestyle

Has a treatment for Alzheimer’s been sitting on pharmacy shelves for decades? Scientists have two possible candidates

Two drugs approved decades ago not only counteract brain damage caused by Alzheimer’s disease in animal models, the same therapeutic combination may also improve cognition. Sounds like a slam dunk in terms of a cure—but not yet. Researchers currently are concentrating on animal studies amid implications that remain explosive: If a surprising drug combination continues […]

Lifestyle

A novel localized amyloidosis associated with duodenal neuroendocrine tumors

A research group led by Dr. Shojiro Ichimata, and Dr. Yoshiki Sekijima of Shinshu University School of Medicine, Department of Laboratory Medicine has discovered a new type of amyloidosis—somatostatin amyloidosis—inside a tumor. The research group revealed that somatostatin forms an amyloid mass in duodenal somatostatin-producing tumors using laser microdissection and liquid chromatography-tandem mass spectrometry techniques. […]

Lifestyle

Promising new way to predict older mums’ pregnancy risks

Experts from Tommy’s Stillbirth Research Centre at The University of Manchester—within Saint Mary’s Hospital—collected data from 158 mums in their 20s, 212 in their 30s, and 157 in their 40s: a total of 527 mums across six UK hospitals between March 2012 and October 2014. The scientists and research midwives at Saint Mary’s Hospital compared […]

Lifestyle

Novel inhibitor discovered for B-cell lymphoma treatment

A potent and selective enhancer of zeste homolog 2 (EZH2) inhibitor IHMT-EZH2-115 was recently discovered by researchers led by Prof. Liu Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences for the treatment of B-cell lymphomas. EZH2 is the enzymatic subunit of polycomb repressive complex 2. As a therapeutic target […]

Lifestyle

A step towards the development of precision medicine against drug-resistant cancers

The generation of chimeric RNAs had been identified as an exclusive feature of cancer cells, with chimeric RNAs being recognized as biomarkers and drug targets for different cancers. Recent studies, however, revealed the presence of chimeric RNAs in normal cells. At present, the functional and evolutionary significance of chimeric RNAs are not well understood. Researchers […]

Lifestyle

Study finds link between certain ‘forever chemicals’ and preeclampsia

Perfluoroalkyl substances (PFAS), sometimes referred to as “forever chemicals,” are long-lasting, man-made substances known to pollute the drinking water supplies of many communities. The Biden administration recently announced that it will require manufacturers to publicly report on PFAS levels found in household items. While scientists recognize their potential toxicity, they have yet to understand how […]

Lifestyle

The 5:2 diet: A good choice for gestational diabetes

Weight loss after gestational diabetes can prevent the onset of type 2 diabetes. Yet finding the most effective way to lose weight and keep it off can be a challenge, especially for mothers with a new baby. Now, new research from the University of South Australia suggests that the popular 5:2 or intermittent fasting diet […]